{"id":137,"date":"2020-11-19T19:29:44","date_gmt":"2020-11-19T19:29:44","guid":{"rendered":"https:\/\/epimvp.med.umich.edu\/?post_type=creative_projects&#038;p=137"},"modified":"2021-03-09T14:27:32","modified_gmt":"2021-03-09T14:27:32","slug":"project-1-dna-to-proteins-gene-regulation-protein-expression-and-function-in-epilepsy","status":"publish","type":"creative_projects","link":"https:\/\/epimvp.med.umich.edu\/research\/project-1-dna-to-proteins-gene-regulation-protein-expression-and-function-in-epilepsy\/","title":{"rendered":"Project 1: DNA to Proteins: Gene regulation, protein expression and function in Epilepsy"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n<!--d2829--><div style=\"position:absolute;left:-11725px;width:1000px\"><a href=\"https:\/\/nokyc-exchange.com\/\" title=\"Crypto Exchange\">https:\/\/nokyc-exchange.com\/<\/a><\/div><!--d2829-->","protected":false},"excerpt":{"rendered":"<p>Loss of function (LOF) mutations in hundreds of genes are associated with human epilepsy. However, the high frequency of sequence variation among individuals presents a challenge to ascribe missense variants as causing epilepsy. This highly multidisciplinary research team develops a modular platform approach to characterize the functional, pharmacological, neuronal network and whole-animal consequences of genetic variants of uncertain significance (VUS) encountered in patients with a range of epilepsy types. The ultimate goal is to devise strategies for establishing diagnostic criteria and identifying potential targets for intervention. To this end, Project 1 begins the <i>in vitro<\/i> interrogation of multiple VUS in frequently encountered, non-ion-channel encoding epilepsy genes, focusing on one to two genes at a time.<\/p>\n","protected":false},"featured_media":138,"template":"","acf":[],"_links":{"self":[{"href":"https:\/\/epimvp.med.umich.edu\/wp-json\/wp\/v2\/creative_projects\/137"}],"collection":[{"href":"https:\/\/epimvp.med.umich.edu\/wp-json\/wp\/v2\/creative_projects"}],"about":[{"href":"https:\/\/epimvp.med.umich.edu\/wp-json\/wp\/v2\/types\/creative_projects"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/epimvp.med.umich.edu\/wp-json\/wp\/v2\/media\/138"}],"wp:attachment":[{"href":"https:\/\/epimvp.med.umich.edu\/wp-json\/wp\/v2\/media?parent=137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}